45 days in Chile & Argentina Itinerary

45 days in Chile & Argentina Itinerary

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Route & dates

45 days in Chile & Argentina Itinerary

Start: San Pedro de Atacama, Chile
1
San Pedro de Atacama, Chile
— 4 nights
shuttle + Fly:  5​h
2
Santiago, Chile
— 4 nights
bus + Fly:  2​h
3
Mendoza, Argentina
— 2 nights
Fly + taxi:  4​h 45​min
4
Cafayate, Argentina
— 3 nights
Drive:  2​h 45​min
5
Salta, Argentina
— 2 nights
Fly:  2​h 15​min
6
Iguazu National Park, Argentina
— 1 night
Fly:  3​h 30​min
7
Buenos Aires, Argentina
— 2 nights
Fly:  5​h 15​min
8
Ushuaia, Argentina
— 8 nights
Fly:  2​h
9
El Calafate, Argentina
— 4 nights
bus:  4​h 30​min
10
Puerto Natales (Torres del Paine), Chile
— 9 nights
bus:  3​h
11
Punta Arenas, Chile
— 3 nights
Fly:  33​h
End: Singapore, Singapore


Learn more about your trip

4
nights
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
You'll discover tucked-away gems like Piedras Rojas and Valle Arcoiris. There's lots more to do: get impressive views of Lascar, contemplate the waterfront views at Lagunas Baltinache, examine the collection at Museo del Meteorito, and explore the striking landscape at Valle De La Luna.

For traveler tips, more things to do, photos, and tourist information, refer to the San Pedro de Atacama planning app .

In September, plan for daily highs up to 27°C, and evening lows to 2°C. Finish your sightseeing early on the 22nd (Sun) so you can travel to Santiago.

Things to do in San Pedro de Atacama

Parks Nature Outdoors
Find places to stay Sep 17 — 22:
Highlights from your plan
Piedras Rojas ©
Piedras Rojas
Lascar ©
Lascar
Laguna Chaxa ©
Laguna Chaxa

4
nights
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
You'll discover tucked-away gems like El Yeso Dam and Vina Undurraga. Step out of Santiago to go to Buin and see Vina Santa Rita, which is approximately 36 minutes away. And it doesn't end there: tour the pleasant surroundings at San Cristóbal Hill, don't miss a visit to Santa Lucia Hill, take in the spiritual surroundings of Santuario de la Inmaculada Concepcion, and do a tasting at Santa Carolina.

To see reviews, traveler tips, and tourist information, read our Santiago trip itinerary planning site .

Traveling by combination of shuttle and flight from San Pedro de Atacama to Santiago takes 5 hours. Alternatively, you can drive; or take a bus. Finish your sightseeing early on the 26th (Thu) to allow enough time to travel to Mendoza.

Things to do in Santiago

Parks Wineries Nature

Side Trips

El Yeso Dam, Vina Santa Rita, Vina Undurraga
Find places to stay Sep 22 — 26:
Highlights from your plan
San Cristóbal Hill ©
San Cristóbal Hill
Cerro Santa Lucia ©
Cerro Santa Lucia
Santuario de la Inmaculada Concepcion ©

2
nights
Mendoza, Argentina

Mendoza ©
Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Start off your visit on the 26th (Thu): walk around Parque General San Martin, ride a horse along Los Pingos Horse Riding, and then learn about winemaking at Bodega Tierras Altas. On your second day here, do a tasting at Bodega Cruzat. Bubbles Experience and then awaken your taste buds at some of the top wineries in the area.

To find photos, maps, ratings, and more tourist information, read our Mendoza online trip itinerary planner .

You can do a combination of bus and flight from Santiago to Mendoza in 2 hours. Alternatively, you can drive; or take a bus. The time zone changes from Chile Time to Argentine Time, which is usually a 1 hour difference. In September, daily temperatures in Mendoza can reach 25°C, while at night they dip to 9°C. Finish your sightseeing early on the 28th (Sat) so you can travel to Cafayate.

Things to do in Mendoza

Tours Parks Outdoors
Find places to stay Sep 26 — 28:
Highlights from your plan
Bodega Tierras Altas ©
Bodega Tierras Altas
Bodega Cruzat. Bubbles Experience ©
Bodega Cruzat. Bubbles Experience
Parque General San Martin ©
Parque General San Martin

3
nights
Cafayate, Argentina

Cafayate ©
Nestled in one of the country's major wine regions, Cafayate and the surrounding area remain a top vacation destination throughout the year.
You'll discover tucked-away gems like La Garganta del Diablo and Quebrada del Rio de las Conchas. There's lots more to do: explore the striking landscape at El Anfiteatro, do a tasting at Bodega El Porvenir de Cafayate, see the interesting displays at Museo de la Vid y el Vino de Cafayate, Salta, Argentina, and tee off at La Estancia De Cafayate.

To see where to stay, photos, and other tourist information, read Cafayate trip itinerary maker site .

Traveling by combination of flight and taxi from Mendoza to Cafayate takes 5 hours. Alternatively, you can drive; or take a bus. Wrap up your sightseeing on the 1st (Tue) to allow time to drive to Salta.

Things to do in Cafayate

Parks Nature Outdoors
Find places to stay Sep 28 — Oct 1:
Highlights from your plan
Garganta del Diablo Salta ©
Garganta del Diablo Salta
El Anfiteatro ©
El Anfiteatro

2
nights
Salta, Argentina

Salta ©
Salta boasts a vibrant social life and array of informative museums appealing to visitors looking for a memorable cultural experience.
Step off the beaten path and head to Virgen de los Tres Cerritos and Iglesia San Francisco. Next up on the itinerary: make a trip to Plaza 9 de Julio, pause for some photo ops at Virgen del Cerro, get engrossed in the history at MAAM - Museo de Arqueologia de Alta Montana de Salta, and take in the spiritual surroundings of Immaculada Madre del Divino Corazon Eucaristico de Jesus.

To find more things to do, traveler tips, ratings, and tourist information, go to the Salta tour itinerary planner .

Traveling by car from Cafayate to Salta takes 3 hours. Alternatively, you can do a combination of taxi and flight; or take a bus. In October, daytime highs in Salta are 30°C, while nighttime lows are 13°C. Finish your sightseeing early on the 3rd (Thu) so you can travel to Iguazu National Park.

Things to do in Salta

Outdoors Historic Sites Tours
Find places to stay Oct 1 — 3:
Highlights from your plan
Virgen de los Tres Cerritos ©
Virgen de los Tres Cerritos
Plaza 9 de Julio ©
Plaza 9 de Julio

1
night
Iguazu National Park, Argentina

Iguazu National Park ©
Iguazu National Park contains 672 sq km (259 sq mi) of fertile subtropical forests, but its main attraction is the majestic Iguazu Falls.
Start off your visit on the 4th (Fri): admire the sheer force of Iguazu Falls and then head off the coast to Isla San Martin.

To find reviews, ratings, more things to do, and other tourist information, use the Iguazu National Park travel route planner .

You can fly from Salta to Iguazu National Park in 2.5 hours. Other options are to drive; or take a bus. Traveling from Salta in October, you can expect nighttime temperatures to be somewhat warmer in Iguazu National Park, with lows of 19°C. Finish your sightseeing early on the 4th (Fri) so you can travel to Buenos Aires.

Things to do in Iguazu National Park

Parks Nature
Find places to stay Oct 3 — 4:
Highlights from your plan
Isla San Martin ©
Isla San Martin
Iguazu Falls ©
Iguazu Falls

2
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Start off your visit on the 5th (Sat): trot along with a tour on horseback, don't miss a visit to Cemiterio de Recoleta, and then admire the landmark architecture of El Ateneo Grand Splendid. Here are some ideas for day two: examine the collection at Fragata ARA Sarmiento, then get a taste of the local shopping with Puerto Madero, then stroll around Rosedal De Palermo, and finally take in nature's colorful creations at Parque 3 de Febrero.

To find ratings, reviews, and other tourist information, you can read our Buenos Aires holiday maker app .

Fly from Iguazu National Park to Buenos Aires in 3.5 hours. Alternatively, you can drive; or take a bus. Traveling from Iguazu National Park in October, expect nights in Buenos Aires to be about the same, around 17°C, while days are a bit cooler, around 24°C. Finish your sightseeing early on the 6th (Sun) so you can travel to Ushuaia.

Things to do in Buenos Aires

Tours Outdoors Parks
Find places to stay Oct 4 — 6:
Highlights from your plan
Cemiterio de Recoleta ©
Cemiterio de Recoleta
Horseback Riding Tours
Rosedal De Palermo ©
Rosedal De Palermo

8
nights
Ushuaia, Argentina

Ushuaia ©
Often called the "End of the World" because of its position on the southernmost tip of South America, the expanding city of Ushuaia serves as both a busy commercial port and attractive tourist hub.
You'll discover tucked-away gems like Lago Roca and Galeria Tematica Historia Fueguina. There's much more to do: see the world from above with a helicopter tour, pause for some photo ops at Plaza Malvinas, make a trip to Les Éclaireurs Lighthouse, and hike along Glaciar Martial.

To find ratings, reviews, maps, and other tourist information, read Ushuaia online trip planner .

Getting from Buenos Aires to Ushuaia by flight takes about 5.5 hours. Other options: do a combination of car and ferry; or take a bus. Traveling from Buenos Aires in October, expect nights in Ushuaia to be cooler, around 3°C, while days are a bit cooler, around 11°C. Finish your sightseeing early on the 14th (Mon) to allow enough time to travel to El Calafate.

Things to do in Ushuaia

Parks Nature Outdoors

Side Trips

Tierra del Fuego National Park, Glaciar Martial
Find places to stay Oct 6 — 14:
Highlights from your plan
Lago Roca ©
Lago Roca
Helicopter Tours
Galeria Tematica Historia Fueguina ©

4
nights
El Calafate, Argentina

El Calafate tourism thrives mostly thanks to the city's proximity to a World Heritage-listed national park, famed for containing over 40 large glaciers.
You'll discover tucked-away gems like Glaciar Spegazzini and Enjoy!. Step out of El Calafate with an excursion to Glaciar Seco in Los Glaciares National Park--about 1h 45 min away. And it doesn't end there: take in the architecture and atmosphere at Santa Teresita del Nino Jesus, explore the striking landscape at Onelli Glacier, surround yourself with nature on a nature and wildlife tour, and look for gifts at El Galpon de Don Emilio.

For traveler tips, other places to visit, reviews, and tourist information, go to the El Calafate travel itinerary planner .

You can fly from Ushuaia to El Calafate in 2 hours. Other options are to do a combination of car and ferry; or take a bus. Expect somewhat warmer evenings in El Calafate when traveling from Ushuaia in October, with lows around 8°C. Cap off your sightseeing on the 18th (Fri) early enough to catch the shuttle to Puerto Natales (Torres del Paine).

Things to do in El Calafate

Outdoors Parks Nature

Side Trip

Los Glaciares National Park
Find places to stay Oct 14 — 18:
Highlights from your plan
Nature & Wildlife Tours
Santa Teresita del Nino Jesus ©
Santa Teresita del Nino Jesus
Glaciar Spegazzini ©
Glaciar Spegazzini

9
nights
Puerto Natales (Torres del Paine), Chile

Surrounded by towering mountains, shimmering lakes, and the region's rugged hills, Puerto Natales serves as a bustling jumping-off point for exploring the Torres del Paine National Park.
Step off the beaten path and head to Kayaking & Canoeing and Horseback Riding Tours. There's lots more to do: don't miss a visit to Muelle Historico, get outside with Patagonia Adventure, take in the dramatic natural features at Glaciar Amalia, and get a taste of life in the country at The Condors Nests.

To find maps, ratings, reviews, and tourist information, read our Puerto Natales (Torres del Paine) tour itinerary builder .

You can take a shuttle from El Calafate to Puerto Natales (Torres del Paine) in 4 hours. Other options are to take a bus; or drive. The time zone difference moving from Argentine Time (ART) to Chile Time (CLT) is minus 1 hour. When traveling from El Calafate in October, plan for a bit warmer days and about the same nights in Puerto Natales (Torres del Paine): temperatures range from 13°C by day to 6°C at night. Cap off your sightseeing on the 27th (Sun) early enough to catcht the bus to Punta Arenas.

Things to do in Puerto Natales (Torres del Paine)

Outdoors Tours Nature
Find places to stay Oct 18 — 27:
Highlights from your plan
Kayaking & Canoeing
Horseback Riding Tours
Muelle Historico ©
Muelle Historico

3
nights
Punta Arenas, Chile

Punta Arenas ©
An erstwhile hub of the sheep wool industry, Punta Arenas has evolved into a gateway of sorts for hikers, cruise ship passengers, and adventure travelers heading out on the windswept lands of Chile's extreme southern reaches.
You'll explore the less-touristy side of things at Faro San Isidro and Cabo Froward. And it doesn't end there: head outdoors with Antarctica21, look for all kinds of wild species at Reserva nacional Magallanes, don't miss a visit to Santuario Maria Auxiliadora, and pause for some serene contemplation at Catedral Sagrado Corazon.

To find where to stay, traveler tips, ratings, and tourist information, you can read our Punta Arenas tour itinerary maker app .

You can take a bus from Puerto Natales (Torres del Paine) to Punta Arenas in 3 hours. Alternatively, you can drive. Traveling from Puerto Natales (Torres del Paine) in October, Punta Arenas is little chillier at night with lows of 3°C. Wrap up your sightseeing on the 30th (Wed) early enough to travel back home.

Things to do in Punta Arenas

Outdoors Parks Historic Sites
Find places to stay Oct 27 — 30:
Highlights from your plan
Antarctica21 ©
Antarctica21
Faro San Isidro ©
Faro San Isidro
Santuario Maria Auxiliadora ©
Santuario Maria Auxiliadora

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